DETERMINATION OF SALBUTAMOL-RELATED IMPURITIES BY CAPILLARY ELECTROPHORESIS

被引：64

作者：

ALTRIA, KD

机构：

[1] Pharmaceutical Analysis, Glaxo Group Research, Ware, Herts. SG12 0DP, Park Road

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 634卷 / 02期

关键词：

D O I：

10.1016/0021-9673(93)83020-S

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper describes the use and capabilities of capillary electrophoresis (CE) in the determination of two dimeric impurities present in salbutamol sulphate drug substance. Acceptable measures of detector linearity of response over the typical impurity range, detection limits, precision of peak area and migration times were obtained. The results obtained by CE were directly compared to those obtained by HPLC and TLC. The data shows agreement between the three techniques.

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页码：323 / 328

页数：6

相关论文

共 28 条

[1] COMPARISON OF ISOTACHOPHORESIS, CAPILLARY ZONE ELECTROPHORESIS AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR THE DETERMINATION OF SALBUTAMOL, TERBUTALINE SULFATE AND FENOTEROL HYDROBROMIDE IN PHARMACEUTICAL DOSAGE FORMS [J].

ACKERMANS, MT ;

BECKERS, JL ;

EVERAERTS, FM ;

SEELEN, IGJA .

JOURNAL OF CHROMATOGRAPHY, 1992, 590 (02) :341-353

[2]

ACKERMANS MT, 1992, J CHROMATOGR, V606, P229

[3] HIGH-VOLTAGE CAPILLARY ZONE ELECTROPHORESIS - OPERATING PARAMETERS EFFECTS ON ELECTROENDOSMOTIC FLOWS AND ELECTROPHORETIC MOBILITIES [J].

ALTRIA, KD ;

SIMPSON, CF .

CHROMATOGRAPHIA, 1987, 24 :527-532

[4] ANALYSIS OF SOME PHARMACEUTICALS BY HIGH-VOLTAGE CAPILLARY ZONE ELECTROPHORESIS [J].

ALTRIA, KD ;

SIMPSON, CF .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1988, 6 (6-8) :801-807

[5] PHARMACEUTICAL ANALYSIS BY CAPILLARY ZONE ELECTROPHORESIS AND MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY [J].

ALTRIA, KD ;

SMITH, NW .

JOURNAL OF CHROMATOGRAPHY, 1991, 538 (02) :506-509

[6]

ALTRIA KD, 1993, IN PRESS CHROMATOGRA, V35

[7]

ALTRIA KD, 1990, CHROMATOGR ANAL AUG, P9

[8] FACTORS INFLUENCING THE RESOLUTION AND QUANTITATION OF OLIGONUCLEOTIDES SEPARATED BY CAPILLARY ELECTROPHORESIS ON A GEL-FILLED CAPILLARY [J].

DEMOREST, D ;

DUBROW, R .

JOURNAL OF CHROMATOGRAPHY, 1991, 559 (1-2) :43-56

[9] INTERNAL STANDARDIZATION TECHNIQUE FOR CAPILLARY ZONE ELECTROPHORESIS [J].

DOSE, EV ;

GUIOCHON, GA .

ANALYTICAL CHEMISTRY, 1991, 63 (11) :1154-1158

[10] DETERMINATION OF INGREDIENTS OF ANTIPYRETIC ANALGESIC PREPARATIONS BY MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY [J].

FUJIWARA, S ;

HONDA, S .

ANALYTICAL CHEMISTRY, 1987, 59 (23) :2773-2776