THE 42-KILODALTON RHOPTRY-ASSOCIATED PROTEIN OF PLASMODIUM-FALCIPARUM

被引：58

作者：

SAUL, A ^{[1
]}

COOPER, J ^{[1
]}

HAUQUITZ, D ^{[1
]}

IRVING, D ^{[1
]}

CHENG, Q ^{[1
]}

STOWERS, A ^{[1
]}

LIMPAIBOON, T ^{[1
]}

机构：

[1] BIOTECH AUSTRALIA,ROSEVILLE,NSW,AUSTRALIA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1992年 / 50卷 / 01期

关键词：

RHOPTRY PROTEIN; MALARIA VACCINE CANDIDATE; PLASMODIUM-FALCIPARUM;

D O I：

10.1016/0166-6851(92)90251-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene coding for a 42-kDa rhoptry protein of Plasmodium falciparum has been cloned. On the basis of prior monkey vaccination studies, this protein is regarded as an important vaccine candidate, but its identity has been the subject of considerable uncertainty. Analysis of the cloned sequence shows that it is a basic, hydrophobic protein, without repetitive elements, unrelated to any of the previously postulated gene products and shows minimal sequence diversity. The availability of the corresponding recombinant protein will enable studies of its efficacy in human vaccine trials to be undertaken.

引用

页码：139 / 150

页数：12

共 47 条

[1]

ANDERS RF, 1983, P NATL ACAD SCI USA, V80, P529

[2]

BRAUNBRETON C, 1988, NATURE, V332, P487

[3] INFECTIVITY TO MOSQUITOS OF PLASMODIUM-FALCIPARUM CLONES GROWN-INVITRO FROM THE SAME ISOLATE [J].