ACTIVATION OF SRC-LIKE PROTEIN-TYROSINE KINASE LYN AND ITS ASSOCIATION WITH PHOSPHATIDYLINOSITOL 3-KINASE UPON B-CELL ANTIGEN RECEPTOR-MEDIATED SIGNALING

被引：243
作者：
YAMANASHI, Y
FUKUI, Y
WONGSASANT, B
KINOSHITA, Y
ICHIMORI, Y
TOYOSHIMA, K
YAMAMOTO, T
机构：
[1] UNIV TOKYO,FAC AGR,DEPT AGR CHEM,BIOCHEM LAB,BUNKYO KU,TOKYO 113,JAPAN
[2] TAKEDA CHEM IND LTD,DIV RES & DEV,CHEM RES LABS,YODOGAWA KU,OSAKA 532,JAPAN
[3] OSAKA UNIV,MICROBIAL DIS RES INST,DEPT ONCOGENE RES,SUITA,OSAKA 565,JAPAN
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 03期
关键词：
MEMBRANE IMMUNOGLOBULIN CROSS-LINKING; LYN GENE PRODUCT; TYROSINE PHOSPHORYLATION;
D O I：
10.1073/pnas.89.3.1118
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Crosslinking of membrane-bound immunoglobulins, which are B-cell antigen receptors, causes proliferation and differentiation of B cells or the inhibition of their growth. The receptor-mediated signaling involves tyrosine phosphorylation of cellular proteins. The Src-like protein-tyrosine kinase Lyn is expressed preferentially in B cells and is an intracytoplasmic constituent of the B-cell antigen receptor complex. Crosslinking of membrane-bound immunoglobulin M with antibody induced rapid increases in the kinase activities of Lyn and Lyn-associated phosphatidylinositol 3-kinase. Crosslinking of B-cell antigen receptor also induced association of Lyn with an 85-kDa noncatalytic subunit of phosphatidyl-inositol 3-kinase. Thus, Lyn is functionally associated with membrane-bound immunoglobulin M and seems likely to participate in B-cell antigen receptor-mediated signaling.
引用
收藏
页码：1118 / 1122
页数：5
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