POLYMORPHIC BEHAVIOR OF SPRAYED LIPID MICROPELLETS AND ITS EVALUATION BY DIFFERENTIAL SCANNING CALORIMETRY AND SCANNING ELECTRON-MICROSCOPY

被引：53

作者：

ELDEM, T ^{[1
]}

SPEISER, P ^{[1
]}

ALTORFER, H ^{[1
]}

机构：

[1] SWISS FED INST TECHNOL,DEPT PHARM,CH-8092 ZURICH,SWITZERLAND

来源：

PHARMACEUTICAL RESEARCH | 1991年 / 8卷 / 02期

关键词：

POLYMORPHISM AND CRYSTALLIZATION OF FATS; TRIGLYCERIDE; SPRAY-DRYING; SPRAY-CONGEALING; DIFFERENTIAL SCANNING CALORIMETRY; SCANNING ELECTRON MICROSCOPY;

D O I：

10.1023/A:1015831801813

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Considering the importance of polymorphism occuring in solid dosage forms causing instability, the polymorphic behaviour of spray-dried and -congealed lipid micropellets was examined by differential scanning calorimetry and scanning electron microscopy. The results showed that both of the spraying processes exert an important effect on their polymorphic and crystallization properties. In spray-drying, due to the rapid solvent evaporation, the obtained lipid micropellets possess an unstable polymorphic form. This unstable form transforms gradually toward a stable form by storage at elevated temperatures. The same modifications were observed with spray-congealed lipid micropellets. The type of glyceride (composition, chain length), solvent and drugs (estradiol cypionate, medroxyprogesterone acetate) and, further, the presence of a stabilizing agent such as lecithin affect the polymorphic transition and its rate.

引用

页码：178 / 184

页数：7

共 13 条

[1]

DEMAN JM, 1985, FOOD MICROSTRUCT, V4, P233

[2] OPTIMIZATION OF SPRAY-DRIED AND SPRAY-CONGEALED LIPID MICROPELLETS AND CHARACTERIZATION OF THEIR SURFACE-MORPHOLOGY BY SCANNING ELECTRON-MICROSCOPY [J].

ELDEM, T ;

SPEISER, P ;

HINCAL, A .

PHARMACEUTICAL RESEARCH, 1991, 8 (01) :47-54

[3]

ELDEM T, 1988, P INT S CONTROL REL, V15, P436

[4]

FUNG HL, 1979, MODERN PHARMACEUTICS

[5]

GARTI N, 1988, CRYSTALLIZATION FATS

[6]

GARTI N, 1983, J AM OIL CHEM SOC, V59, P181

[7] POLYMORPHISM AND TRANSFORMATION ENERGETICS OF SATURATED MONOACID TRIGLYCERIDES FROM DIFFERENTIAL SCANNING CALORIMETRY AND THEORETICAL MODELING [J].

HAGEMANN, JW ;

ROTHFUS, JA .

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1983, 60 (06) :1123-1131

[8]

HAGEMANN JW, 1988, CRYSTALLIZATION FATS

[9] POLYMORPHISM OF INTERESTERIFIED TRIGLYCERIDES AND TRIGLYCERIDE MIXTURES [J].

HERNQVIST, L ;

HERSLOF, B ;

HERSLOF, M .

FETTE SEIFEN ANSTRICHMITTEL, 1984, 86 (10) :393-397

[10] DIGLYCERIDES AS A STABILIZER OF THE BETA-'-CRYSTAL FORM IN MARGARINES AND FATS [J].

HERNQVIST, L ;

ANJOU, K .

FETTE SEIFEN ANSTRICHMITTEL, 1983, 85 (02) :64-66

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