KINETICS OF NUCLEOPHILIC-SUBSTITUTION REACTIONS OF POLYFLUOROAROMATIC COMPOUNDS

This treatment summarises experimental data on the kinetics of nucleophilic substitution reactions in the polyfluoroaromatic series. The review discusses the effects of substituent, solvent, and nucleophilic reagent on the rate and orientation of the nucleophilic aromatic substitution. The additivity of ring fluorine effect on the reactivity of a substrate is considered. The review gives quantitative estimation of the reactivity of polyfluorinated bicyclic and nitrogen-containing heretocyclic compounds and discusses the rate-determining effects. The data on the reaction of the fluorine anion with polyfluoroaromatic compounds are reviewed. © 1990.