PERCUTANEOUS-ABSORPTION IN EXPERIMENTAL EPIDERMAL DISEASE

被引：29
作者：
SOLOMON, AE
LOWE, NJ
机构：
[1] UNIV CALIF LOS ANGELES,DIV DERMATOL,LOS ANGELES,CA 90024
[2] SCRIPPS CLIN & RES FDN,DEPT DERMATOL,LA JOLLA,CA 92037
来源：
BRITISH JOURNAL OF DERMATOLOGY | 1979年 / 100卷 / 06期
关键词：
D O I：
10.1111/j.1365-2133.1979.tb08078.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Little is known about the absorption of topical drugs in epidermal disease associated with epidermal proliferation and altered keratinization. An abnormal hairless mouse epidermis was produced by three different methods: ultraviolet light irradiation, topical vitamin A acid and topical acetic acid. An increased epidermal thickness resulted and the in vitro percutaneous absorption of 0.1% (4‐ 14C) hydrocortisone was found to be increased when compared with normal hairless mouse epidermis. This is evidence for defective skin barrier function in experimental epidermal disease. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：717 / 722
页数：6
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