PLACEBO-CONTROLLED, DOUBLE-BLIND CLINICAL-TRIAL OF ALPRENOLOL IN AFRICAN HYPERTENSIVE PATIENTS

被引：19

作者：

SALAKO, LA ^{[1
]}

FALASE, AO ^{[1
]}

FADEKEADEROUNMU, A ^{[1
]}

机构：

[1] UNIV COLL HOSP IBADAN,DEPT MED,IBADAN,NIGERIA

来源：

CURRENT MEDICAL RESEARCH AND OPINION | 1979年 / 6卷 / 05期

关键词：

Adrenergic Beta Receptor Blockaders; Alprenolol; Blacks; Hypertension; Nigeria;

D O I：

10.1185/03007997909109451

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A placebo-controlled, double-blind clinical trial of alprenolol was carried out in 20 hypertensive Africans. The active drug and placebo were each administered for 8 weeks using a crossover design. Alprenolol was given in the form of a slow-release tablet preparation at a dosage of 200 mg twice daily. Four patients were withdrawn from the study either because of side-effects (2 patients) or non-compliance (2 patients). The mean reduction in blood pressure obtained in the 16 patients who completed the trial was less than that usually reported in Caucasians. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：358 / 363

页数：6

共 18 条

[1]

ABLAD B, 1967, ACTA PHARMACOL TOX, VS 25, P85

[2]

BENGTSSON C, 1972, ACTA MED SCAND, V192, P415

[3] PROPRANOLOL INHIBITION OF RENIN SECRETION - SPECIFIC APPROACH TO DIAGNOSIS AND TREATMENT OF RENIN-DEPENDENT HYPERTENSIVE DISEASES [J].