Potential therapeutic application of adult stem cells in acute respiratory distress syndrome

被引:3
|
作者
Jiang Jian-xin [1 ]
Li Li [1 ]
机构
[1] Third Mil Med Univ, Inst Surg Res, State Key Lab Trauma Burns & Combined Injury, Chongqing 400042, Peoples R China
关键词
Respiratory distress syndrome; adult; Stem cells; Lung injury;
D O I
10.3760/cma.j.issn.1008-1275.2009.04.008
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Acute respiratory distress syndrome (ARDS) remains a poor prognosis in spite of the recent development of new therapeutic strategies. Cell-based therapy with stem cells has been considered as a promising way for the treatment of vital organ damage. Putative endogenous stem cells have been shown to be located within the adult lung in the basal layer of the upper airways, within or near pulmonary neuroendocrine cell rests, at the bronchoalveolar junction, as well as within the alveolar epithelium. These stem cells are hypothesized to be the source of lung regeneration and repair. But this mechanism seems to be insufficient after lung injury. There is increasing excitement over the last few years with the suggestion that exogenous stem cells may offer new treatment options for ARDS. Exogenous stem cells have the ability to differentiate and function as both airway and lung parenchymal epithelial cells in both in vitro and increasingly in vivo experiments. However, there is great controversy concerning the repair effect of adult stem cells in lung injury. This review evaluates the advances in endogenous respiratory stem cells, and assesses the evidence for the use of stem cells in the repair of lung injury.
引用
收藏
页码:228 / 233
页数:6
相关论文
共 50 条
  • [1] Therapeutic implications of mesenchymal stem cells in acute lung injury/acute respiratory distress syndrome
    Yan-Yang Wang
    Xiu-Zhong Li
    Li-Bing Wang
    Stem Cell Research & Therapy, 4
  • [2] Therapeutic Potential and Mechanisms of Action of Mesenchymal Stromal Cells for Acute Respiratory Distress Syndrome
    Curley, Gerard F.
    Scott, Jeremy A.
    Laffey, John G.
    CURRENT STEM CELL RESEARCH & THERAPY, 2014, 9 (04) : 319 - 329
  • [3] Mesenchymal Stem Cells: A Promising Therapy for the Acute Respiratory Distress Syndrome
    Cardenes, Nayra
    Caceres, Eder
    Romagnoli, Militza
    Rojas, Mauricio
    RESPIRATION, 2013, 85 (04) : 267 - 278
  • [4] Mesenchymal Stem Cells Reconditioned in Their Own Serum Exhibit Augmented Therapeutic Properties in the Setting of Acute Respiratory Distress Syndrome
    Xu, Amy L.
    Rodriguez, Luis A., II
    Walker, Kerfoot P., III
    Mohammadipoor, Arezoo
    Kamucheka, Robin M.
    Cancio, Leopoldo C.
    Batchinsky, Andriy, I
    Antebi, Ben
    STEM CELLS TRANSLATIONAL MEDICINE, 2019, 8 (10) : 1092 - 1106
  • [5] The Therapeutic Effects of Methylprednisolone and Surfactant in Acute Respiratory Distress Syndrome in a Rat Model
    Dogan, Nazim
    Aykan, Seyda
    Atalay, Canan
    Gundogdu, Cemal
    Keles, M. Sait
    TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, 2011, 31 (03): : 679 - 685
  • [6] Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome
    Robinson, Matthew John
    Krasnodembskaya, Anna D.
    EUROPEAN RESPIRATORY REVIEW, 2020, 29 (156): : 1 - 10
  • [7] Acute respiratory distress syndrome: Imaging of the injured lung
    Desai, SR
    CLINICAL RADIOLOGY, 2002, 57 (01) : 8 - 17
  • [8] Innate Lymphoid Cells and Acute Respiratory Distress Syndrome
    Chen, Kong
    Kolls, Jay K.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193 (04) : 350 - 352
  • [9] Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 infection: optimizing the therapeutic potential
    Gorman, Ellen
    Millar, Jonathan
    McAuley, Danny
    O'Kane, Cecilia
    EXPERT REVIEW OF RESPIRATORY MEDICINE, 2021, 15 (03) : 301 - 324
  • [10] Mesenchymal stromal cells and the acute respiratory distress syndrome (ARDS): challenges for clinical application
    Millar, J. E.
    Fraser, J. F.
    McAuley, D. F.
    THORAX, 2015, 70 (07) : 611 - 612