Immunosuppression for interstitial lung disease in systemic sclerosis

被引：18

作者：

Cappelli, Susanna ^{[1
]}

Guiducci, Serena ^{[1
]}

Randone, Silvia Bellando ^{[1
]}

Cerinic, Marco Matucci ^{[1
]}

机构：

[1] Univ Florence, DENOthe Ctr, Dept Biomed, Div Rheumatol, Viale Pieraccini 18, I-50139 Florence, Italy

来源：

EUROPEAN RESPIRATORY REVIEW | 2013年 / 22卷 / 129期

关键词：

D O I：

10.1183/09059180.00001813

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The efficacy of immunosuppressors in the treatment of systemic sclerosis-interstitial lung disease is still matter of controversy. In this review we will analyse the evidence that immunosuppressors, despite not being able to reverse fibrotic changes, may help in slowing disease progression. Induction treatment with cyclophosphamide should be started as soon as possible in patients at risk for progression. Mycophenolate mofetil and rituximab have to be considered in patients who are unable to tolerate cyclophosphamide. After remission, maintenance treatment with mycophenolate mofetil or azathioprine should be started in order to preserve the benefits achieved during the induction treatment.

引用

页码：236 / 243

页数：8

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