THIAZOLE CARBOXANILIDE FUNGICIDES - A NEW STRUCTURE-ACTIVITY RELATIONSHIP FOR SUCCINATE-DEHYDROGENASE INHIBITORS

Structure-activity relationships have been examined for a series of thiazole carboxanilides as inhibitors of succinate dehydrogenase. Electron-withdrawing and lipophilic effects are important parameters with regard to the anilide ring. Electron-withdrawing effects along with steric limitations are also important in the thiazole 2-position. Maximization of this unique structure activity relationship led to the synthesis of the most powerful succinate dehydrogenase inhibitors yet reported. This succinate dehydrogenase inhibitory activity was found to translate directly to high fungitoxicity toward Rhizoctonia solani (Kuhn).