THE PATHWAY OF HEMOGLOBIN DEGRADATION IN MALARIA PARASITES

被引：54
作者：
GOLDBERG, DE
SLATER, AFG
机构：
[1] WASHINGTON UNIV,DEPT MED,ST LOUIS,MO 63110
[2] PICOWER INST MED RES,MANHASSET,NY 11030
来源：
PARASITOLOGY TODAY | 1992年 / 8卷 / 08期
关键词：
D O I：
10.1016/0169-4758(92)90146-S
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Hemoglobin degradation in malaria parasites appears to be a vital and massive undertaking during intraerythrocytic development. An ordered pathway exists that efficiently catabolizes hemoglobin to yield amino acids that the parasite uses as a nutrient source, and that co-ordinates the resultant heme into a remarkable crystalline structure called hemozoin. Daniel Goldberg and Andrew Slater explain that the enzymes involved are specific and present prime targets for chemotherapeutic intervention.
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页码：280 / 283
页数：4
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