CRYSTAL-STRUCTURE OF 3-METHOXY-ESTRA-1,3,5(10)TRIENE-16-ALPHA-BR,17-ALPHA-OH

被引：1
作者：
SZULZEWSKY, K
机构：
来源：
KRISTALL UND TECHNIK-CRYSTAL RESEARCH AND TECHNOLOGY | 1979年 / 14卷 / 12期
关键词：
D O I：
10.1002/crat.19790141206
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The steroid 3‐Methoxy‐estra‐1,3,5(10)triene‐16αBr,17αOH crystallizes in the orthorhombic space group P 212121 with lattice constants a = 30.653(5) Å, b = 9.039(2) Å, c = 6.098(1) Å. The single molecule has an intramolecular OH… Br interaction. Intermolecular interactions are only of van der Waals type. Ring A is nearly planar, ring B has a nearly half chair conformation, ring C has a chair conformation and ring D an envelope conformation. Copyright © 1979 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
引用
收藏
页码：1445 / 1451
页数：7
相关论文
共 50 条
[41]   ESTRA-1,3,5(10),16-TETRAENE-3,16-DIOL DIACETATE AND AN EASY SYNTHETIC ROUTE TO 16BETA,17ALPHA- AND 16ALPHA,17ALPHA- STEROIDAL GLYCOLS [J].
RHONE, JR ;
HUFFMAN, MN .
TETRAHEDRON LETTERS, 1965, (19) :1395-&
[42]   TRITIUM LABELING OF A NEW STEROID WITH ANTIFERTILITY PROPERTIES - 3-METHOXY-14-BETA, 15-BETA-METHYLENE [9-ALPHA,11-ALPHA-H-3]-ESTRA-1,3,5(10)-TRIENE-17-BETA-OL [J].
WAGNER, H ;
ROMER, J ;
KASCH, H .
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1981, 18 (11) :1611-1620
[43]   C-13-NMR INVESTIGATIONS OF STEROIDS .4. SUBSTITUENT EFFECTS OF 16-MONOSUBSTITUTED AND 16,17-DISUBSTITUTED 3-METHOXY-ESTRA-1,3,5(10)-TRIENES [J].
ENGELHARDT, G ;
ZEIGAN, D ;
SCHONECKER, B .
ORGANIC MAGNETIC RESONANCE, 1979, 12 (11) :628-630
[44]   STEREOSPECIFIC D-HOMOANNULATION OF 17-HYDROXY-3-METHOXYESTRA-1,3,5(10)-TRIENE-17ALPHA-CARBOXALDEHYDE [J].
MILLER, TC .
JOURNAL OF ORGANIC CHEMISTRY, 1969, 34 (12) :3829-&
[45]   TOTAL SYNTHESIS OF OPTICALLY-ACTIVE STEROIDS .16. PREPARATION OF 1,3,17 BETA-TRIACETOXY-8 ALPHA-ESTRA-1,3,5(10)-TRIENE, AN IMPEDED ESTROGEN [J].
EDER, U ;
HAFFER, G ;
NEEF, G ;
PREZEWOWSKY, K ;
SAUER, G ;
WIECHERT, R .
CHEMISCHE BERICHTE-RECUEIL, 1978, 111 (03) :939-943
[46]   SYNTHESIS OF 15,16,17-TRISUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-METHYL ETHERS [J].
SCHUBERT, G ;
PONSOLD, K ;
TRESSELT, D ;
SCHONECKER, B .
PHARMAZIE, 1975, 30 (12) :817-817
[47]   17α-(4-chlorobenzoyloxy)-3-methoxy-13α-gona-1,3,5(10)-triene [J].
Kuhl, A ;
Schollmeyer, D ;
Schurmann, M ;
Preut, H ;
Kreiser, W .
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1998, 54 :521-523
[48]   PENTACYCLIC STEROIDS .5. TOTAL SYNTHESIS OF 4,6BETA-ETHANO-3-METHOXY-8ALPHA-ESTRA-1,3,5(10)-TRIEN-17BETA-OL AND 4,6ALPHA-ETHANO-3-METHOXYESTRA-1,3,5(10),8,14-PENTAEN-17-ONE [J].
GHOSH, AC ;
HAZRA, BG ;
KARUPNIELSEN, I ;
KANE, MJ ;
HAWKE, D ;
DUAX, WL ;
WEEKS, CM .
JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (05) :683-688
[49]   SYNTHESIS OF 3-METHOXY-18-METHYL-1,3,5(10),15-OSTRATETRAEN-17-ALPHA-OL [J].
HOFMEISTER, H ;
ANNEN, K ;
CLEVE, G ;
LAURENT, H ;
WIECHERT, R .
LIEBIGS ANNALEN DER CHEMIE, 1981, (11) :1973-1981
[50]   ANIMAL-EXPERIMENTS ON ESTROGENIC AND ANTI-OESTROGENIC EFFECTS OF 17ALPHA-THIOCYANOMETHYL-17BETA-TETRAHYDROPYRANYLOXYOESTRA-1,3,5(10)-TRIENE-3-METHYLETHER AND 17BETA-PHENYLAMINOCARBONYLOESTRA-1,3,5(10)-TRIENE-3-METHYLETHER [J].
STRECKE, J ;
IVANENKO, T ;
FEDOTOW, V ;
SCHWETZOW, J .
PHARMAZIE, 1977, 32 (10) :598-602
12345