17-BETA-ESTRADIOL, 5-ALPHA-DIHYDROTESTOSTERONE, PROGESTERONE AND CORTISOL RECEPTORS IN NORMAL AND NEOPLASTIC HUMAN-ENDOMETRIUM

被引：20

作者：

PRODI, G ^{[1
]}

DEGIOVANNI, C ^{[1
]}

GALLI, MC ^{[1
]}

GOLA, G ^{[1
]}

GRILLI, S ^{[1
]}

ROCCHETTA, R ^{[1
]}

ORLANDI, C ^{[1
]}

机构：

[1] UNIV BOLOGNA, IST CLIN OSTET & GINECOL 2, I-40126 BOLOGNA, ITALY

来源：

TUMORI JOURNAL | 1979年 / 65卷 / 02期

关键词：

D O I：

10.1177/030089167906500214

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using the value of 0.24 fmoles/μg DNA as breaking point between high and low binding capacities, the authors quantified receptors for 17β-estradiol (ER), 5α-dihydrotestosterone (DHTR), progesterone (PR) and cortisol (CR) in normal and neoplastic human uterine tissues. Concerning receptor occurrence, significant relationships were observed between ER and PR, ER and DHTR, and DHTR and PR. A direct correlation between the presence of ER and tumor grading was found: PR was less frequent in grade II and absent in grade III endometrial carcinoma; however this was not a significant correlation. In endometrial carcinoma at least 1 of the receptors was detected in 67-91% of the cases, 3 receptors (ER, DHTR, PR) in 56%, and all 4 receptors in 45%. The simultaneous detection of multiple receptors could play an important role in determining hormone response.

引用

页码：241 / 253

页数：13

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