FURTHER FAMILY STUDIES ON GENETIC CONTROL OF BETA2-GLYCOPROTEIN I CONCENTRATION IN HUMAN SERUM

88 families with a total of 213 children were examined for β2-glycoprotein I serum concentrations. In 74 families parents and children had normal concentrations. In 9 families one of the parents and approximately half of the children had intermediate concentrations. These individuals are presumably heterozygous for a deficiency gene BgD. In these families β2-glycoprotein I concentration appears to be controlled by a pair of alleles which are transmitted as autosomal co-dominants. The results in 5 families did not conform to this genetic hypothesis, since children with an intermediate concentration of β2-glycoprotein I were found whose both parents had a normal concentration of this protein. Non-genetic factors may be responsible for phenotypic variations in the different genetic types. © 1969 Springer-Verlag.