CONFORMATION OF XYLOCHOLINE

被引：19

作者：

COGGON, P

MCPHAIL, AT

ROE, AM

机构：

[1] Department of Chemistry, Duke University, Durham, NC

[2] Research Institute, Smith Kline and French Laboratories Limited, Welwyn Garden City

来源：

NATURE | 1969年 / 224卷 / 5225期

关键词：

D O I：

10.1038/2241200a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THE biological activity of quaternary aryloxyethylammonium salts is critically dependent on the nature and position of the substituents in the aromatic ring1-3. Thus choline phenyl ether bromide is a potent nicotine-like ganglion stimulant2,4, whereas its 2,6-dimethyl analogue (xylocholine) is devoid of ganglion stimulant activity5 but was the first compound to exhibit adrenergic neurone blocking activity6-9. Xylocholine also has muscarine-like properties6-9. © 1969 Nature Publishing Group.

引用

页码：1200 / &

共 21 条

[1] ARYLOXYALKYLAMINOGUANIDINES . THEIR SYNTHESIS AND BIOLOGICAL PROPERTIES [J].