CONVERSION, INVITRO, OF (7N-H-3) TESTOSTERONE TO ESTRONE AND ESTRADIOL-17-BETA AND THEIR 3-SULFATE CONJUGATE BY GUINEA-PIG PLACENTA

被引：14

作者：

ADESSI, GL ^{[1
]}

GOUTTECOUSSIEU, C ^{[1
]}

NHUAN, TQ ^{[1
]}

EICHENBERGER, D ^{[1
]}

JAYLE, MF ^{[1
]}

机构：

[1] CNRS, UER BIOMED, LAB 87, F-75270 PARIS 6, FRANCE

来源：

STEROIDS | 1978年 / 32卷 / 03期

关键词：

D O I：

10.1016/0039-128X(78)90082-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Different cellular fractions of guinea-pig placenta were incubated in the presence of (7n-3H) testosterone. Microsomal aromatization of 3H-testosterone into estrone and estradiol-17β was demonstrated in the presence of NADPH. The predominance of estrone after incubation with 17β-hydroxylated precursors, (7n-3H) testosterone and (6,7-3H) estradiol-17β, indicate that there is a microsomal 17β-hydroxysterold dehydrogenase activity. In this report, cytosolic sulfurylation of estrogens is demonstrated. This latter activity represents a quite original characteristic of the placental metabolism of estrogens in guinea-pigs. In contrast with the human placenta where there is considerable sulfatase activity, the guinea-pig placenta can sulfurylate estrogens. © 1978.

引用

页码：295 / 306

页数：12

共 17 条

[1]

ADESSI G, 1974, CR ACAD SCI D NAT, V279, P2143

[2] GAS-CHROMATOGRAPHY PROFILE OF ESTROGENS - APPLICATION TO PREGNANCY URINE [J].