COLLAGEN-LIKE FRAGMENTS - EXCRETION IN URINE OF PATIENTS WITH HAGETS DISEASE OF BONE

被引：62

作者：

KRANE, SM

MUNOZ, AJ

HARRIS, ED

机构：

来源：

SCIENCE | 1967年 / 157卷 / 3789期

关键词：

D O I：

10.1126/science.157.3789.713

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Patients with Paget''s disease of bone excrete, in the urine, polypeptides that have amino acid composition and other properties resembling those of fragments of collagen. The pattern of isotope incorporation in vivo suggests that these fragments are derived from collagen that has been synthesized and rapidly degraded, or that they are rapidly synthesized but not incorporated into tropocollagen molecules.

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页码：713 / +

页数：1

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共 20 条

[1] RENATURATION OF SOLUBLE COLLAGEN . PRODUCTS FORMED AT DIFFERENT TEMPERATURES [J].

BEIER, G ;

ENGEL, J .

BIOCHEMISTRY, 1966, 5 (08) :2744-&

[2] INTRINSIC COTTON EFFECTS IN COLLAGEN AND POLY-L-PROLINE [J].

BLOUT, ER ;

CARVER, JP ;

GROSS, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (05) :644-&

[3] SUBUNITS OF HYDROXYLAMINE-TREATED TROPOCOLLAGEN [J].

BLUMENFELD, OO ;

ROJKIND, M ;

GALLOP, PM .

BIOCHEMISTRY, 1965, 4 (09) :1780-+

[4] DEUX GLYCOPETIDES A HYDROXPROLINE DANS LURINE HUMAINE NORMALE [J].

BOURRILLON, R ;

VERNAY, JL .

BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 117 (02) :319-+

[5]

CHERIAN MG, 1965, BIOCHIM BIOPHYS ACTA, V101, P241

[6] PAGETS DISEASE OF BONE - CLINICAL + METABOLIC OBSERVATIONS [J].

DEDEUXCHAISNES, CN ;

KRANE, SM .

MEDICINE, 1964, 43 (03) :233-+

[7] URINARY HYDROXYPROLINE AS AN INDEX OF COLLAGEN TURNOVER IN BONE [J].

DULL, TA ;

HENNEMAN, PH .

NEW ENGLAND JOURNAL OF MEDICINE, 1963, 268 (03) :132-&

[8] BIOPHYSICS - 3,2,1, - A B C SUB-UNIT HYPOTHESIS FOR ALPHA-CHAINS OF TROPOCOLLAGEN [J].

GALLOP, PM .

NATURE, 1966, 209 (5018) :73-&

[9] ORGANIZATION OF COLLAGEN IN BONE - ROLE OF NONCOVALENT BONDS IN RELATIVE INSOLUBILITY OF BONE COLLAGEN [J].

GLIMCHER, MJ ;

KATZ, EP .

JOURNAL OF ULTRASTRUCTURE RESEARCH, 1965, 12 (5-6) :705-+

[10] A MODIFIED PROCEDURE FOR RADIOACTIVE HYDROXYPROLINE ASSAY IN URINE AND TISSUES AFTER LABELED PROLINE ADMINISTRATION [J].

LEROY, EC ;

HARRIS, ED ;

SJOERDSMA, A .

ANALYTICAL BIOCHEMISTRY, 1966, 17 (03) :377-+