THE ASYMMETRIC-SYNTHESIS OF NONPEPTIDE CCK-A RECEPTOR AGONISTS

被引：11

作者：

BURGAUD, BGM

HORWELL, DC

PRITCHARD, MC

BERNAD, N

MARTINEZ, J

机构：

[1] ADDENBROOKES HOSP,PARKE DAVIS NEUROSCI RES CTR,CAMBRIDGE CB2 2QB,ENGLAND

[2] FAC PHARM MONTPELLIER,CNRS,URA,F-34060 MONTPELLIER,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 05期

关键词：

D O I：

10.1016/0957-4166(95)00130-H

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The asymmetric synthesis, CCK receptor binding affinities and CCK-A agonist properties of a novel series of non-peptide CCK-A receptor selective ligands is reported.

引用

页码：1081 / 1084

页数：4

共 8 条

[1] MODEL STUDIES TOWARDS THE APPLICABILITY OF THE READILY AVAILABLE (S)-N-TRITYLASPARTIC ANHYDRIDE IN THE SYNTHESIS OF AMINO-ACIDS AND PEPTIDES [J].

ATHANASSOPOULOS, C ;

TZAVARA, C ;

PAPAIOANNOU, D ;

SINDONA, G ;

MAIA, HLS .

TETRAHEDRON, 1995, 51 (09) :2679-2688

[2] THE RATIONAL DESIGN AND SYNTHESIS OF NONPEPTIDE RHEGNYLOGUES OF CCK-26-33 - A NOVEL SERIES OF CCK-A SELECTIVE LIGANDS [J].

BOURNE, GT ;

HORWELL, DC ;

PRITCHARD, MC .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (05) :889-894

[3] ENANTIOSPECIFIC SYNTHESIS WITH AMINO-ACIDS .1. TRYPTOPHAN AS A CHIRON FOR THE SYNTHESIS OF ALPHA-SUBSTITUTED TRYPTOPHAN DERIVATIVES [J].

BOURNE, GT ;

CRICH, D ;

DAVIES, JW ;

HORWELL, DC .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (07) :1693-1699

[4] PHARMACOLOGICAL PROPERTIES OF GR38032F, A NOVEL ANTAGONIST AT 5-HT3 RECEPTORS [J].

BUTLER, A ;

HILL, JM ;

IRELAND, SJ ;

JORDAN, CC ;

TYERS, MB .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 94 (02) :397-412

[5] BIOLOGICAL ACTIONS OF CHOLECYSTOKININ [J].

CRAWLEY, JN ;

CORWIN, RL .

PEPTIDES, 1994, 15 (04) :731-755

[6] RATIONALLY DESIGNED DIPEPTOID ANALOGS OF CCK - ALPHA-METHYLTRYPTOPHAN DERIVATIVES AS HIGHLY SELECTIVE AND ORALLY ACTIVE GASTRIN AND CCK-B ANTAGONISTS WITH POTENT ANXIOLYTIC PROPERTIES [J].

HORWELL, DC ;

HUGHES, J ;

HUNTER, JC ;

PRITCHARD, MC ;

RICHARDSON, RS ;

ROBERTS, E ;

WOODRUFF, GN .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) :404-414

[7]

JENSEN RT, 1982, J BIOL CHEM, V257, P5554

[8] CYCLIC TAUTOMERS OF TRYPTOPHANS AND TRYPTAMINES .4. SYNTHESIS OF CYCLIC TAUTOMERS OF TRYPTOPHANS AND TRYPTAMINES [J].

TANIGUCHI, M ;

HINO, T .

TETRAHEDRON, 1981, 37 (08) :1487-1494

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