TUMOR-CYTOTOXICITY AND PRODUCTION OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR FROM BLOOD MONOCYTES OF CERVICAL-CARCINOMA PATIENTS

被引：0
作者：
NADKARNI, JJ
DE, AK
JHAVER, KJ
KAMAT, MR
机构：
来源：
NEOPLASMA | 1994年 / 41卷 / 02期
关键词：
CERVICAL CARCINOMA; CYTOTOXICITY; INTERFERON-GAMMA; INTERLEUKIN-1; MONOCYTES; TUMOR NECROSIS FACTOR-ALPHA;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To assess the functional integrity of monocytes in patients with cervical carcinoma, cytotoxic potential of peripheral blood monocytes and their ability to secrete interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) after activation with different stimulating agents were studied. Comparable Levels of monocyte-mediated cytotoxicity were observed in healthy donors and patients. The production of IL-1 and TNF-alpha by monocytes of healthy donors and patients was similar indicating no defect in monocyte functions in these patients.
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页码：123 / 128
页数：6
相关论文
共 38 条
[11]  
FREY JR, 1987, LYMPHOKINE RES, V6, P215
[12]   IMPAIRMENT OF MONOCYTE FUNCTIONS IN ADVANCED HEAD AND NECK-CANCER [J].
GARRAUD, O ;
FAUCHER, A ;
LEGRAND, E .
IMMUNOLOGY LETTERS, 1988, 18 (03) :213-218
[13]   CYTO-TOXICITY TO TUMOR-CELLS OF MONOCYTES FROM NORMAL INDIVIDUALS AND CANCER-PATIENTS [J].
GERRARD, TL ;
TERZ, JJ ;
KAPLAN, AM .
INTERNATIONAL JOURNAL OF CANCER, 1980, 26 (05) :585-593
[14]   THE EFFECT OF GAMMA-INTERFERON ON IL-1 SECRETION OF INVITRO DIFFERENTIATED HUMAN MACROPHAGES [J].
HAQ, AU ;
RINEHART, JJ ;
MACA, RD .
JOURNAL OF LEUKOCYTE BIOLOGY, 1985, 38 (06) :735-746
[15]   MONOCYTE-KILLER AND NATURAL-KILLER CELL-MEDIATED SPONTANEOUS CYTOTOXICITY AGAINST HUMAN NONCULTURED SOLID TUMOR-CELLS [J].
ITOH, K ;
PLATSOUCAS, CD ;
BALCH, CM .
CELLULAR IMMUNOLOGY, 1987, 108 (02) :495-500
[16]   PRODUCTION OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR IN NON-HODGKINS-LYMPHOMA PATIENTS [J].
JHAVER, K ;
DE, A ;
ADVANI, S ;
NADKARNI, J .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 1991, 34 (02) :123-127
[17]  
KLEINERMAN ES, 1983, CANCER RES, V43, P2010
[18]  
LE JM, 1983, J IMMUNOL, V131, P2821
[19]  
LOVETT D, 1986, J IMMUNOL, V136, P340
[20]  
LOWENTHAL JW, 1986, J IMMUNOL, V137, P1226
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