A PHASE OF LIPOSOMES WITH ENTANGLED TUBULAR VESICLES

被引：89
作者：
CHIRUVOLU, S
WARRINER, HE
NARANJO, E
IDZIAK, SHJ
RADLER, JO
PLANO, RJ
ZASADZINSKI, JA
SAFINYA, CR
机构：
[1] UNIV CALIF SANTA BARBARA, DEPT CHEM ENGN,MAT RES LAB, SANTA BARBARA, CA 93106 USA
[2] UNIV CALIF SANTA BARBARA, DEPT MAT,MAT RES LAB, SANTA BARBARA, CA 93106 USA
[3] UNIV CALIF SANTA BARBARA, DEPT PHYS, SANTA BARBARA, CA 93106 USA
[4] UNIV CALIF SANTA BARBARA, BIOCHEM & MOLEC BIOL PROGRAM, SANTA BARBARA, CA 93106 USA
[5] EXXON RES & ENGN CO, ANNANDALE, NJ 08801 USA
来源：
SCIENCE | 1994年 / 266卷 / 5188期
关键词：
D O I：
10.1126/science.7973704
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
An equilibrium phase belonging to the family of bilayer liposomes in ternary mixtures of dimyristoylphosphatidylcholine (DMPC), water, and geraniol (a biological alcohol derived from oil-soluble vitamins that acts as a cosurfactant) has been identified. Electron and optical microscopy reveal the phase, labeled L(tv), to be composed of highly entangled tubular vesicles. In situ x-ray diffraction confirms that the tubule walls are multilamellar with the lipids in the chain-melted state. Macroscopic observations show that the L(tv) phase coexists with the well-known L(4) phase of spherical vesicles and a bulk L(alpha) phase. However, the defining characteristic oi the L(tv) phase is the Weissenberg rod climbing effect under shear, which results from its polymer-like entangled microstructure.
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收藏
页码：1222 / 1225
页数：4
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