LIPID-PEROXIDATION IN RATS INTOXICATED WITH 3-NITROPROPIONIC ACID

被引：36

作者：

FU, YT ^{[1
]}

HE, FS ^{[1
]}

ZHANG, SL ^{[1
]}

ZHANG, JS ^{[1
]}

机构：

[1] CHINESE ACAD PREVENT MED,INST OCCUPAT MED,BEIJING 100050,PEOPLES R CHINA

来源：

TOXICON | 1995年 / 33卷 / 03期

关键词：

D O I：

10.1016/0041-0101(94)00173-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Using an electron spin resonance technique, free radical signals were observed to be increased in liver of rats 15, 30 and 45 min after orally dosing with 80 mg/kg 3-nitropropionic acid (3-NPA). Concentrations of 3-NPA from 595 to 2380 mg/litre enhanced the formation of adrenochrome from adrenaline in mitochondria and microsome suspensions of liver and brain. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) as well as the content of malonidialdehyde (MDA) were significantly increased in liver of rats dosed with 80 mg/kg 3-NPA. There was also a cerebral increase of activity of SOD and content of MDA. These results suggest that 3-NPA is able to produce lipid peroxidation both in vivo and in vitro.

引用

页码：327 / 331

页数：5

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