LYMPHOPROLIFERATION DISORDER IN MICE EXPLAINED BY DEFECTS IN FAS ANTIGEN THAT MEDIATES APOPTOSIS

被引：2573

作者：

WATANABEFUKUNAGA, R

BRANNAN, CI

COPELAND, NG

JENKINS, NA

NAGATA, S

机构：

[1] OSAKA BIOSCI INST,6-2-4 FURUEDAI,SUITA,OSAKA 565,JAPAN

[2] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,FREDERICK,MD 21701

来源：

NATURE | 1992年 / 356卷 / 6367期

关键词：

D O I：

10.1038/356314a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumour necrosis factor receptor and nerve growth factor receptor. Mice carrying the lymphoproliferation (lpr) mutation have defects in the Fas antigen gene. The lpr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus.

引用

页码：314 / 317

页数：4

共 34 条

[1] DIFFERENCES DEFINED BY BONE-MARROW TRANSPLANTATION SUGGEST THAT LPR AND GLD ARE MUTATIONS OF GENES ENCODING AN INTERACTING PAIR OF MOLECULES [J].