IMPROVED PRACTICAL SYNTHESIS OF A PROSTAGLANDIN AND CARBOCYCLIC NUCLEOSIDE SYNTHON

被引：15

作者：

HUDLICKY, T

NATCHUS, MG

NUGENT, TC

机构：

[1] Department of Chemistry, Virginia Polytechnic Institute and State University, Virginia 24061, Blacksburg

来源：

SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/00397919208021086

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, four step synthesis of chiral enone 2a [(+)-2,3-(isopropylidenedioxy)-4-cyclopentenone] from diol 1a (X = Cl), available from microbial oxidation of chlorobenzene, is described. This synthesis is a vast improvement over that previously reported and compares very favorably with others in the literature.

引用

页码：151 / 157

页数：7

共 19 条

[1]

ALI SM, 1990, TETRAHEDRON LETT, V31, P1509

[2] L-ERYTHRURONIC ACID-DERIVATIVES AS BUILDING-BLOCKS FOR NUCLEOSIDE ANALOGS - SYNTHESIS OF 4'-C-ARYL-D-RIBONUCLEOSIDES [J].