THE PROGNOSTIC VALUE OF DNA CONTENT MEASURED BY IMAGE CYTOMETRY IN SOFT-TISSUE SARCOMAS

被引：3
作者：
PAPE, H
POTTGEN, C
PLOEM, JS
VANDRIELKULKER, AMJ
WURM, R
SCHMITT, G
机构：
[1] UNIV DUSSELDORF,DEPT RADIOTHERAPY & RADIAT ONCOL,W-4000 DUSSELDORF 1,GERMANY
[2] LEIDEN UNIV,DEPT CYTOCHEM & CYTOMETRY,SYLVIUS LABS,2300 RA LEIDEN,NETHERLANDS
来源：
ANNALS OF ONCOLOGY | 1992年 / 3卷
关键词：
DNA CONTENT; IMAGE CYTOMETRY; SOFT TISSUE SARCOMA;
D O I：
10.1093/annonc/3.suppl_2.S89
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Nuclear DNA content in soft tissue sarcoma was determined by image cytometry using archival, paraffin embedded material. In a retrospective study 138 specimens of 81 patients have been analysed. The ploidy level was correlated to clinical outcome regarding tumor volume and histological grading, the most important prognostic parameters. Ploidy has a significant prognostic value and correlates well with histological grading (p = 0.01). Tumour volume was found to be an independent prognostic factor (p = > 0.1) [chi(2) test]. The DNA content of the primary tumour and of multiple local recurrences remained similar.
引用
收藏
页码：S89 / S92
页数：4
相关论文
共 10 条
  • [1] CELLULAR DNA CONTENT AND PROGNOSIS OF HIGH-GRADE SOFT-TISSUE SARCOMA - THE SCANDINAVIAN-SARCOMA-GROUP EXPERIENCE
    ALVEGARD, TA
    BERG, NO
    BALDETORP, B
    FERNO, M
    KILLANDER, D
    RANSTAM, J
    RYDHOLM, A
    AKERMAN, M
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1990, 8 (03) : 538 - 547
  • [2] AUER G, 1984, CANCER RES, V44, P394
  • [3] KREICBERGS A, 1987, CANCER, V59, P128, DOI 10.1002/1097-0142(19870101)59:1<128::AID-CNCR2820590126>3.0.CO
  • [4] 2-G
  • [5] MAZANET R, 1991, CANCER-AM CANCER SOC, V68, P463, DOI 10.1002/1097-0142(19910801)68:3<463::AID-CNCR2820680304>3.0.CO
  • [6] 2-E
  • [7] AUTOMATED CELL ANALYSIS FOR DNA STUDIES OF LARGE CELL-POPULATIONS USING THE LEYTAS IMAGE CYTOMETRY SYSTEM
    PLOEM, JS
    VANDRIELKULKER, AMJ
    PLOEMZAAIJER, JJ
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 1989, 185 (05) : 671 - 675
  • [8] RODENBURG CJ, 1987, CANCER RES, V47, P3938
  • [9] TANKE HJ, 1989, PROSTATE, P297
  • [10] PREPARATION OF MONOLAYER SMEARS FROM PARAFFIN-EMBEDDED TISSUE FOR IMAGE CYTOMETRY
    VANDRIELKULKER, AMJ
    MESKER, WE
    VANVELZEN, I
    TANKE, HJ
    FEICHTINGER, J
    PLOEM, JS
    [J]. CYTOMETRY, 1985, 6 (03): : 268 - 272
1