THE EFFECT OF PEROXISOME PROLIFERATORS ON S-PHASE SYNTHESIS IN PRIMARY CULTURES OF FISH HEPATOCYTES

被引：8

作者：

BALDWIN, LA

KOSTECKI, PT

CALABRESE, EJ

机构：

[1] Environmental Public Health Center, University of Massachusetts, Amherst

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 1993年 / 25卷 / 02期

关键词：

D O I：

10.1006/eesa.1993.1018

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The ability of seven structurally diverse peroxisome proliferators to induce S-phase synthesis was studied in primary cultures of rainbow trout and medaka hepatocytes. Cells were maintained in serum-free conditions designed to facilitate attachment, viability, and function. Lead nitrate, a well-known and potent rodent liver mitogen was used in vitro in trout and medaka and in vivo in trout to evaluate the capacity of the species and our system to respond to mitogenic stimuli. S-phase synthesis induced by peroxosome proliferators did not result in any statistically significant increase over control cultures. These in vitro results are supported by in vivo data previously obtained and the present work with lead nitrate. © 1993 Academic Press, Inc.

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页码：193 / 201

页数：9

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