SPECIFIC METAPHASE AND INTERPHASE DETECTION OF THE BREAKPOINT REGION IN 8Q24 OF BURKITT-LYMPHOMA CELLS BY TRIPLE-COLOR FLUORESCENCE INSITU HYBRIDIZATION

被引：85
作者：
RIED, T
LENGAUER, C
CREMER, T
WIEGANT, J
RAAP, AK
VANDERPLOEG, M
GROITL, P
LIPP, M
机构：
[1] UNIV HEIDELBERG,INST HUMAN GENET & ANTHROPOL,NEUENHEIMER FELD 328,W-6900 HEIDELBERG,GERMANY
[2] LEIDEN UNIV,FAC MED,DEPT CYTOCHEM & CYTOMETRY,2300 RA LEIDEN,NETHERLANDS
[3] UNIV MUNICH,INST BIOCHEM,W-8000 MUNICH 2,GERMANY
来源：
GENES CHROMOSOMES & CANCER | 1992年 / 4卷 / 01期
关键词：
D O I：
10.1002/gcc.2870040109
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Triple fluorescence in situ hybridization with a plasmid DNA library from sorted human chromosomes 8 in combination with bacteriophage clones flanking the breakpoint in 8q24 of the Burkitt lymphoma cell line JI was used for the specific delineation of this breakpoint in individual tumor cells. With this approach, tumor-specific breakpoints in translocation chromosomes can be detected at all stages of the cell cycle with high specificity.
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页码：69 / 74
页数：6
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