HIGHER CORTICAL DYSFUNCTION, ANTIPHOSPHOLIPID ANTIBODIES AND NEURORADIOLOGICAL EXAMINATIONS IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：19
作者：
MAESHIMA, E
YAMADA, Y
YUKAWA, S
NOMOTO, H
机构：
[1] From the Third Department of Internal Medicine, Wakayama Medical College, Wakayama
来源：
INTERNAL MEDICINE | 1992年 / 31卷 / 10期
关键词：
NEUROPSYCHOLOGICAL EXAMINATIONS; BRAIN CT; SINGLE PHOTON EMISSION CT; LUPUS ANTICOAGULANT; ANTICARDIOLIPIN ANTIBODIES;
D O I：
10.2169/internalmedicine.31.1169
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We performed neuropsychological tests to investigate higher cortical dysfunction in 21 patients with systemic lupus erythematosus (SLE). We also measured antiphospholipid antibodies bodies (APA), performed brain computed tomography (CT), and obtained a single photon emission CT (SPECT) to measure regional cerebral blood flow (rCBF) in order to elucidate a possible relationship between APA and higher cortical dysfunction. Higher cortical dysfunction was noted in as many as 16 (76%) out of 21 cases. APA were positive in 8 (38%) out of 21 cases. Although the relationship between APA and higher cortical dysfunction was not significant, patients positive for lupus anticoagulant (LA) were found to have higher cortical dysfunction. Brain CT revealed at least one abnormality in 6 cases (29%) but none had a localized lesion, SPECT disclosed a reduced rCBF in 9 cases (43%). The findings on brain CT and SPECT were unrelated to higher cortical dysfunction.
引用
收藏
页码：1169 / 1174
页数：6
相关论文
共 33 条
  • [1] Dubois E.L., Wallace D.J., Clinical and Laboratory Manifestations of Systemic Lupus Erythematosus, Dubois, Lupus Erythematosus, (1987)
  • [2] Dalmas J.F., Mandilaharsu C., Lupus eritematoso diseminado comenzando por desestructuracion de las funciones superiores del sistema nervioso central, Acta Neurol Latinoamer, 26, (1980)
  • [3] Carbotte R.M., Denburg S.D., Denburg J.A., Prevalence of cognitive impairment in systemic lupus erythematosus, J Nerv Ment Dis, 174, (1986)
  • [4] Nagaoka S., Tani K., Chiba J., Et al., Study on psychological tests applied to patients with systemic lupus erythematosus, The Ryumachi, 23, (1983)
  • [5] Tan E.M., Cohen A.S., Fries J.F., Et al., The 1982 revised criteria for the classification of systemic lupus erythematosus, Arthritis Rheum, 25, (1982)
  • [6] Folstein M.F., Folstein S.E., McHugh P.R., Mini-Mental State. A practical method for grading the cognitive state of patients for the clinician, J Psychiatr Res, 12, (1975)
  • [7] Hasegawa K., Examination of senile psychological function, (1977)
  • [8] Watamori T., Assessment of higher cortical functions. 1. Aphasia, Sogo Reh abiriteshon, 10, (1982)
  • [9] Kato M., Sano Y., Uno A., Constructive deficits in brain damaged patients. Effect of the localized and/or duffuse cerebral lesions, Higher Brain Function Research, 8, (1988)
  • [10] Sirridge M.S., Shannon R., Lupus anticoagulant (Tissue thromboplastin ihibitor test), Laboratory Evaluation of Hemostasis and Thrombosis, (1983)
1234