VOLATILE N-NITROSAMINES IN MAINSTREAM CIGARETTE-SMOKE - OCCURRENCE AND FORMATION

被引：0
|
作者：
TRICKER, AR [1 ]
PREUSSMANN, R [1 ]
机构：
[1] GERMAN CANC RES CTR,INST TOXICOL & CHEMOTHERAPIE,W-6900 HEIDELBERG 1,GERMANY
来源：
CLINICAL INVESTIGATOR | 1992年 / 70卷 / 3-4期
关键词：
NITROSAMINE; CIGARETTE SMOKE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Analytical data is presented for the occurrence of the three major volatile N-nitrosamines in cigarette tobacco and mainstream smoke, namely N-nitrosodimethylamine (NDMA), N-nitrosoethylmethylamine (NEMA) and N-nitrosopyrrolidine (NPYR) as well as for the occurrence of the corresponding precursor amines and non-volatile N-nitrosamino acids in tobacco. Experimental studies using the C20 reference cigarette show that NPYR present in mainstream smoke results from direct transfer of preformed NPYR (ca. 1.5%), decarboxylation of N-nitrosoproline in tobacco (ca. 10%), pyrolytic nitrosation of pyrrolidine in tobacco (ca. 37%) and concerted decarboxylation/nitrosation of proline (ca. 52%) during tobacco pyrolysis.
引用
收藏
页码：283 / 289
页数：7
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