NEUROPSYCHOPHARMACOLOGICAL STUDY OF 2,4-DIHYDRO[1,2,4] TRIAZOLO[3,4-C][1,4]BENZOTHIAZINE-1-ONE (IDPH-791)

被引：7
|
作者：
JUNNARKAR, AY
SINGH, PP
PATNAIK, GK
SHROTRI, DS
机构：
[1] IDPL RES CTR, DEPT PHARMACOL, DIV BIOL, BALANAGAR TOWNSHIP, HYDERABAD 500037, INDIA
[2] BJ MED COLL, DEPT PHARMACOL, Pune 411001, INDIA
[3] CENT DRUG RES INST, DEPT PHARMACOL, LUCKNOW 226001, UTTAR PRADESH, INDIA
来源：
PHARMACOLOGICAL RESEARCH | 1992年 / 26卷 / 02期
关键词：
IDPH-791; TRIAZOLOBENZOTHIAZINE; CENTRALLY-ACTING MUSCLE RELAXANT; NEUROPSYCHOPHARMACOLOGICAL STUDY;
D O I：
10.1016/S1043-6618(05)80126-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The neuropsychopharmacological profile of a new centrally acting skeletal muscle relaxant, 2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzothiazine-1-one (IDPH-791), an analogue of triazolobenzothiazine, has been described and compared to mephenesin, a well known centrally-acting muscle relaxant. IDPH-791 was found to be safer and of longer duration of action than mephenesin in all the tests conducted in this study. Both IDPH-791 and mephenesin caused ataxia, decrease in spontaneous activity and inhibition of pinnal reflex. IDPH-791 was 1.5 to 2.0 times more potent in exhibiting motor inco-ordination and anticonvulsant activity than mephenesin in mice and rats. IDPH-791 was twice as active in inhibiting various spinal polysynaptic reflexes, crossed extensor, flexor, and linguomandibular reflexes; however, both did not affect the typical monosynaptic reflex, patellar reflex. IDPH-791 and mephenesin did not have sedative activity. Although mephenesin exhibited haemolytic activity, IDPH-791 was devoid of this activity. It is concluded that IDPH-791 is a safe and effective centrally-acting muscle relaxant having a longer duration of action than mephenesin. IDPH-791 is also devoid of sedative and haemolytic activity. © 1992 The Italian Pharmacological Society.
引用
收藏
页码：131 / 141
页数：11
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