DIFFERENTIAL INDUCTION OF BRAIN, LUNG AND LIVER NITRIC-OXIDE SYNTHASE BY ENDOTOXIN IN THE RAT

被引：408
作者：
KNOWLES, RG
MERRETT, M
SALTER, M
MONCADA, S
机构：
[1] Wellcome Research Laboratories, Beckenham, Kent
来源：
BIOCHEMICAL JOURNAL | 1990年 / 270卷 / 03期
关键词：
D O I：
10.1042/bj2700833
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation.
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页码：833 / 836
页数：4
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