EFFECTS OF CAFFEINE ON THE EXPRESSION OF POTENTIALLY LETHAL AND SUBLETHAL DAMAGE IN GAMMA-IRRADIATED CULTURED MAMMALIAN-CELLS

被引：24

作者：

SCHROY, CB ^{[1
]}

TODD, P ^{[1
]}

机构：

[1] PENN STATE UNIV,DEPT BIOCHEM & BIOPHYS,UNIVERSITY PK,PA 16802

来源：

RADIATION RESEARCH | 1979年 / 78卷 / 02期

关键词：

D O I：

10.2307/3575047

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Caffeine was found to potentiate single-dose cobalt γ-ray-induced lethality in human T-1 and Chinese hamster V79-79 cells when present at 2.0 to 2.5 mM for 21 to 48 hr after irradiation. In split-dose experiments, 2 mM caffein apparently did not affect survival when present only for the 4 hr between doses. As 4 hr is sufficient time for these cells to complete sublethal damage repair it is concluded that caffeine affects the expression of potentially lethal damage but not the expression of sublethal damage.

引用

页码：312 / 316

页数：5

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