THE DECREASED LEVEL OF CASEIN KINASE-2 IN BRAIN CORTEX OF SCHIZOPHRENIC AND ALZHEIMERS-DISEASE PATIENTS

被引：44

作者：

AKSENOVA, MV ^{[1
]}

BURBAEVA, GS ^{[1
]}

KANDROR, KV ^{[1
]}

KAPKOV, DV ^{[1
]}

STEPANOV, AS ^{[1
]}

机构：

[1] AN BAKH BIOCHEM INST,MOSCOW,USSR

来源：

FEBS LETTERS | 1991年 / 279卷 / 01期

关键词：

CASEIN KINASE-2; BRAIN; SCHIZOPHRENIA; ALZHEIMERS DISEASE;

D O I：

10.1016/0014-5793(91)80249-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The content of casein kinase 2 is considerably decreased in ribosome-free extracts of the frontal cortex of schizophrenic and Alzheimer's disease patients in comparison to normal brains as has been demonstrated by means of immunoblotting. The activity of casein kinase 2 towards endogenous substrates and casein is also diminished in the cases of mental pathologies examined. This phenomenon may explain the well-known aberrations in the phosphorylation of structural proteins of human brain which are intrinsic for the mental diseases.

引用

页码：55 / 57

页数：3

共 19 条

[1] A CASEIN KINASE-II RELATED ACTIVITY IS INVOLVED IN PHOSPHORYLATION OF MICROTUBULE-ASSOCIATED PROTEIN MAP-1B DURING NEURO-BLASTOMA CELL-DIFFERENTIATION [J].