DOXORUBICIN (ADRIAMYCIN) - A CRITICAL-REVIEW OF FREE RADICAL-DEPENDENT MECHANISMS OF CYTOTOXICITY

被引：453
作者：
KEIZER, HG
PINEDO, HM
SCHUURHUIS, GJ
JOENJE, H
机构：
[1] FREE UNIV AMSTERDAM,INST HUMAN GENET,POB 7161,1007 MC AMSTERDAM,NETHERLANDS
[2] FREE UNIV AMSTERDAM,DEPT ONCOL,1007 MC AMSTERDAM,NETHERLANDS
来源：
PHARMACOLOGY & THERAPEUTICS | 1990年 / 47卷 / 02期
关键词：
D O I：
10.1016/0163-7258(90)90088-J
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The antineoplastic drug doxorubicin is capable of generating a variety of free radical species in subcellular systems and this capacity has been considered critical for its antitumor action. However, for most tumor cell lines this mechanism of cytotoxicity does not appear to play a major role. Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin. © 1990.
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页码：219 / 231
页数：13
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