PHARMACOKINETICS OF TINIDAZOLE IN THE HORSE

被引：7

作者：

PYORALA, S ^{[1
]}

KOTILAINEN, T ^{[1
]}

SILVENNOINEN, P ^{[1
]}

HANNINEN, U ^{[1
]}

MERO, M ^{[1
]}

KAARTINEN, L ^{[1
]}

机构：

[1] ORION PHAMACEUT CO, SF-02101 ESPOO, FINLAND

来源：

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS | 1990年 / 13卷 / 01期

关键词：

D O I：

10.1111/j.1365-2885.1990.tb00750.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Serum tinidazole concentrations were monitored in five clinically healthy adult horses after intravenous (i.v.) and oral administration of the drug (15 mg/kg and 25 mg/kg, respectively). After i.v. administration, the mean residence time was 7.0 h, the elimination half‐life 5.2 h and the body clearance rate 1.6 ml/min/kg. The distribution volume was found to be 660 ml/kg. After oral administration, the mean residence time was 8.5 h, the absorption half‐life 1.1 h and the bioavailability essentially 100%. In view of the in‐vitro sensitivities of various anaerobic bacteria, a dosage of 10‐15 mg/kg of tinidazole, orally, at 12‐h intervals, can be recommended for the treatment of anaerobic infections in horses. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：76 / 80

页数：5

共 15 条

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