The Fetal Safety of Benzodiazepines: An Updated Meta-analysis

被引：7
|
作者：
Enato, Ehijie [1 ,2 ]
Moretti, Myla [1 ]
Koren, Gideon [1 ]
机构：
[1] Hosp Sick Children, Div Clin Pharmacol & Toxicol, Motherisk Program, Toronto, ON, Canada
[2] Univ Benin, Dept Clin Pharm, Benin, Nigeria
来源：
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA | 2011年 / 33卷 / 01期
关键词：
Benzodiazepine; teratogenicity; malformation risk;
D O I：
10.1016/S1701-2163(16)34772-7
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Benzodiazepines are commonly used by women of reproductive age, and hence many pregnant women are exposed to them. An updated meta-analysis of their fetal safety synthesized nine studies with over one million pregnancies, yielding an odds ratio of 1.07 (95% CI 0.91 to 1.25). While benzodiazepines do not appear to increase teratogenic risk in general, case-controls suggest a twofold increased risk of oral cleft.
引用
收藏
页码：46 / 48
页数：3
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