THE E5 TRANSFORMING PROTEINS OF THE PAPILLOMAVIRUSES

被引：11
作者：
DIMAIO, D
PETTI, L
HWANG, ES
机构：
[1] Department of Genetics, Yale University School of Medicine, New Haven, CT 06510
来源：
SEMINARS IN VIROLOGY | 1994年 / 5卷 / 05期
关键词：
RECEPTORS; SIGNAL TRANSDUCTION; KERATINOCYTES; PDGF RECEPTOR; TRANSFORMATION;
D O I：
10.1006/smvy.1994.1041
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The E5 proteins are short, hydrophobic transforming proteins encoded by many of the papillomaviruses. The 44 amino acid E5 protein of bovine papillomavirus efficiently transforms cultured fibroblasts and interacts with a variety of cellular proteins. Considerable evidence implicates the PDGF beta receptor as an important mediator of the transforming activity of the BPV E5 protein in fibroblasts. Other potential targets of the BPV E5 protein include the EGF receptor, a subunit of the the vacuolar H+ - ATPase, and a protein related to alpha-adaplin. The E5 transforming proteins of the human papillomaviruses may interact with similar cellular targets in keratinocytes.
引用
收藏
页码：369 / 379
页数：11
相关论文
共 52 条
[31]   ACTIVATION OF CELL-GROWTH BY BINDING OF FRIEND SPLEEN FOCUS-FORMING VIRUS GP55 GLYCOPROTEIN TO THE ERYTHROPOIETIN RECEPTOR [J].
LI, JP ;
DANDREA, AD ;
LODISH, HF ;
BALTIMORE, D .
NATURE, 1990, 343 (6260) :762-764
[32]   THE BOVINE PAPILLOMAVIRUS-E5 TRANSFORMING PROTEIN CAN STIMULATE THE TRANSFORMING ACTIVITY OF EGF AND CSF-1 RECEPTORS [J].
MARTIN, P ;
VASS, WC ;
SCHILLER, JT ;
LOWY, DR ;
VELU, TJ .
CELL, 1989, 59 (01) :21-32
[33]   HUMAN PAPILLOMAVIRUS TYPE-6B DNA REQUIRED FOR INITIATION BUT NOT MAINTENANCE OF TRANSFORMATION OF C127 MOUSE CELLS [J].
MORGAN, D ;
PECORARO, G ;
ROSENBERG, I ;
DEFENDI, V .
JOURNAL OF VIROLOGY, 1990, 64 (03) :969-976
[34]   OPEN READING FRAME-E6 AND FRAME-E7 OF BOVINE PAPILLOMAVIRUS TYPE-1 ARE BOTH REQUIRED FOR FULL TRANSFORMATION OF MOUSE C127 CELLS [J].
NEARY, K ;
DIMAIO, D .
JOURNAL OF VIROLOGY, 1989, 63 (01) :259-266
[35]   PLATELET-DERIVED GROWTH-FACTOR RECEPTOR CAN MEDIATE TUMORIGENIC TRANSFORMATION BY THE BOVINE PAPILLOMAVIRUS E5 PROTEIN [J].
NILSON, LA ;
DIMAIO, D .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (07) :4137-4145
[36]   GENETIC DEFINITION OF A NEW BOVINE PAPILLOMAVIRUS TYPE-1 OPEN READING FRAME, E5B, THAT ENCODES A HYDROPHOBIC PROTEIN INVOLVED IN ALTERING HOST-CELL PROTEIN PROCESSING [J].
OBANION, MK ;
WINN, VD ;
SETTLEMAN, J ;
YOUNG, DA .
JOURNAL OF VIROLOGY, 1993, 67 (06) :3427-3434
[37]   THE PRODUCTS OF THE E5, E6, OR E7 OPEN READING FRAMES OF RHPV-1 CAN INDIVIDUALLY TRANSFORM NIH-3T3 CELLS OR IN COTRANSFECTIONS WITH ACTIVATED RAS CAN TRANSFORM PRIMARY RODENT EPITHELIAL-CELLS [J].
OSTROW, RS ;
LIU, ZJ ;
SCHNEIDER, JF ;
MCGLENNEN, RC ;
FORSLUND, K ;
FARAS, AJ .
VIROLOGY, 1993, 196 (02) :861-867
[38]   ACTIVATION OF THE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR BY THE BOVINE PAPILLOMAVIRUS-E5 TRANSFORMING PROTEIN [J].
PETTI, L ;
NILSON, LA ;
DIMAIO, D .
EMBO JOURNAL, 1991, 10 (04) :845-855
[39]   SPECIFIC INTERACTION BETWEEN THE BOVINE PAPILLOMAVIRUS E5 TRANSFORMING PROTEIN AND THE BETA-RECEPTOR FOR PLATELET-DERIVED GROWTH-FACTOR IN STABLY TRANSFORMED AND ACUTELY TRANSFECTED CELLS [J].
PETTI, L ;
DIMAIO, D .
JOURNAL OF VIROLOGY, 1994, 68 (06) :3582-3592
[40]   STABLE ASSOCIATION BETWEEN THE BOVINE PAPILLOMAVIRUS-E5 TRANSFORMING PROTEIN AND ACTIVATED PLATELET-DERIVED GROWTH-FACTOR RECEPTOR IN TRANSFORMED MOUSE CELLS [J].
PETTI, L ;
DIMAIO, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) :6736-6740
123456