IN-VIVO TIME AND DOSE-DEPENDENCY OF INTERLEUKIN-6 SECRETION IN RESPONSE TO LOW-DOSE SUBCUTANEOUS RECOMBINANT INTERLEUKIN-2

被引：13

作者：

MEFFERT, M ^{[1
]}

HANNINEN, EL ^{[1
]}

MENZEL, T ^{[1
]}

SCHOMBURG, A ^{[1
]}

DUENSING, S ^{[1
]}

DALLMANN, I ^{[1
]}

GROSSE, J ^{[1
]}

VOCKE, S ^{[1
]}

BUER, J ^{[1
]}

DECKERT, M ^{[1
]}

HILSE, R ^{[1
]}

KIRCHNER, H ^{[1
]}

POLIWODA, H ^{[1
]}

ATZPODIEN, J ^{[1
]}

机构：

[1] HANNOVER MED SCH,HAMATOL & ONKOL ABT 6860,D-30623 HANNOVER,GERMANY

来源：

CANCER BIOTHERAPY | 1994年 / 9卷 / 04期

关键词：

INTERLEUKIN-2; INTERLEUKIN-6; RENAL CELL CARCINOMA;

D O I：

10.1089/cbr.1994.9.307

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Serum concentrations of Interleukin-6 (IL-6) were determined in renal cell carcinoma patients treated with low-dose subcutaneous human recombinant interleukin-2 (rIL-2). In all patients, administration of rIL-2 resulted in a significant increase in IL-6 serum levels to peak values within 4 to 6 hours as measured by enzyme-linked immunosorbent assays (ELISA). Repetitive administration of rIL-2 induced significantly lower IL-6 serum peaks when compared to the initial administration of rIL-2. Cumulative IL-6 release, as expressed by the area under the concentration curve (AUC), appeared to be independent of rIL-2 dose distribution (10 million IU rIL-2/m2 versus 20 million IU rIL-2/m2), and IL-6 serum peaks showed no direct dose dependency. Prior rIL-2 immunotherapy had no measurable effect on rIL-2 induced IL-6 release, while steroids resulted in a significant suppression of secondary IL-6. Release of IL-6 did not correlate with response to rIL-2 therapy or survival of rIL-2 treated renal cell carcinoma patients.

引用

页码：307 / 316

页数：10

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