Levels of superoxide dismutase mRNA in rat lens: Effect of aging

被引：2

作者：

Devamanoharan, PS ^{[1
]}

Farrell, R ^{[1
]}

Varma, SD ^{[1
]}

机构：

[1] UNIV MARYLAND,DEPT OPHTHALMOL,BALTIMORE,MD 21201

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1995年 / 152卷 / 02期

关键词：

superoxide dismutase; mRNA; lens; aging; gene transcription; cataract;

D O I：

10.1007/BF01076080

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Superoxide dismutase, the enzyme catalyzing the dismutation of O-2 .(-) to H2O2 is known to be present in various ocular and nonocular tissues. In this communication we have determined the gene expression of this enzyme in rat lenses. The investigations have been conducted as a function of age using RNase protection assay. These in vitro assays for the corresponding mRNA suggested that the transcription of the gene is age variant, increasing as a function of age. The levels were significantly lower in the young lenses in comparison to the older lenses.

引用

页码：175 / 178

页数：4

共 10 条

[1]

BHUYAN KC, 1981, IRCS MED SCI-BIOCHEM, V9, P195

[2]

CAMERON LL, 1983, INVEST OPHTHALMOL S, P202

[3] PREVALENCE AND ETIOLOGY OF CATARACT IN PUNJAB [J].