MIF PROTEINS ARE NOT GLUTATHIONE TRANSFERASE HOMOLOGS

被引：0

作者：

PEARSON, WR

机构：

来源：

PROTEIN SCIENCE | 1994年 / 3卷 / 03期

关键词：

GLUTATHIONE TRANSFERASE; HOMOLOGY; INHIBITORY FACTOR; MACROPHAGE MIGRATION; SEQUENCE SIMILARITY;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although macrophage migration inhibitory factor (MIF) proteins conjugate glutathione, sequence analysis does not support their homology to other glutathione transferases. Glutathione transferases are not detected with MIF proteins in searches of protein sequence databases, and MIF proteins do not share significant sequence similarity with glutathione transferases. Homology cannot be demonstrated by multiple sequence alignment or evolutionary tree construction; such methods assume that the proteins being analyzed are homologous.

引用

页码：525 / 527

页数：3

共 6 条

[1] MIF PROTEINS ARE THETA-CLASS GLUTATHIONE-S-TRANSFERASE HOMOLOGS
BLOCKI, FA
ELLIS, LBM
WACKETT, LP
[J]. PROTEIN SCIENCE, 1993, 2 (12) : 2095 - 2102
[2] RAT-LIVER PROTEIN LINKING CHEMICAL AND IMMUNOLOGICAL DETOXIFICATION SYSTEMS
BLOCKI, FA
SCHLIEVERT, PM
WACKETT, LP
[J]. NATURE, 1992, 360 (6401) : 269 - 270
[3] DEJONG JL, 1988, J BIOL CHEM, V263, P8430
[4] METHODS FOR ASSESSING THE STATISTICAL SIGNIFICANCE OF MOLECULAR SEQUENCE FEATURES BY USING GENERAL SCORING SCHEMES
KARLIN, S
ALTSCHUL, SF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (06) : 2264 - 2268
[5] AN EVOLUTIONARY PERSPECTIVE ON GLUTATHIONE TRANSFERASES INFERRED FROM CLASS-THETA GLUTATHIONE TRANSFERASE CDNA SEQUENCES
PEMBLE, SE
TAYLOR, JB
[J]. BIOCHEMICAL JOURNAL, 1992, 287 : 957 - 963
[6] PATTERN-INDUCED MULTI-SEQUENCE ALIGNMENT (PIMA) ALGORITHM EMPLOYING SECONDARY STRUCTURE-DEPENDENT GAP PENALTIES FOR USE IN COMPARATIVE PROTEIN MODELING
SMITH, RF
SMITH, TF
[J]. PROTEIN ENGINEERING, 1992, 5 (01): : 35 - 41

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