THE ZINC MEDIATED CONDENSATION OF AMINO-ACID ESTERS WITH IMINES TO BETA-LACTAMS

被引：2

作者：

JASTRZEBSKI, JTBH ^{[1
]}

VANKOTEN, G ^{[1
]}

机构：

[1] UNIV UTRECHT,DEBYE INST,DEPT MET MEDIATED SYNTHESIS,PADUALAAN 8,3584 CH UTRECHT,NETHERLANDS

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80954-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An experimentally attractive stereoselective 'One Pot' synthesis of beta-lactams is described. This route is based on the zinc mediated condensation of an alpha-amino acid ester with an imine via a zinc ester enolate. Making use of proper substituents in both the amino acid ester and the imine the stereochemistry of the C-C bond forming step can be completely controlled.

引用

页码：2351 / 2356

页数：6

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