The TNBS-induced colitis animal model: An overview

被引：251

作者：

Antoniou, Efstathios ^{[1
]}

Margonis, Georgios Antonios ^{[1
]}

Angelou, Anastasios ^{[2
]}

Pikouli, Anastasia ^{[2
]}

Argiri, Paraskevi ^{[3
]}

Karavokyros, Ioannis ^{[2
]}

Papalois, Apostolos ^{[4
]}

Pikoulis, Emmanouil ^{[2
]}

机构：

[1] Univ Athens, Sch Med, Laiko Hosp, Dept Propaedeut Surg 2, Athens, Greece

[2] Univ Athens, Sch Med, Laiko Hosp, Dept Surg 1, Athens, Greece

[3] Larissa Gen Hosp, CT MRI Dept, Larisa 41221, Greece

[4] ELPEN, Expt Res Ctr, Athens, Greece

来源：

ANNALS OF MEDICINE AND SURGERY | 2016年 / 11卷

关键词：

TNBS; Colitis; Crohn's disease; Animal model;

D O I：

10.1016/j.amsu.2016.07.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Despite recent advances the pathogenesis of Crohn's disease remains incompletely understood. A variety of animal models have been utilized in an effort to provide further insights and develop more therapeutic options. In order to simulate, to an extent, the pathogenesis and the clinical course of the disease, TNBS induced colitis is often used. Various approaches for inducing TNBS-colitis have been described in the literature. Methods/results: In this review, we sought to present the animal model of TNBS induced colitis and outline the pathogenesis, pathophysiology, clinical course and pathological characteristics of the model. Furthermore, we describe the differences among those protocols regarding types of animals and colitis induction. Data sources: The MEDLINE database was thoroughly searched using the keywords: TNBS, colitis, Crohn's disease, animal model. Two investigators independently reviewed the abstracts and appropriate articles were included in this review. Additional articles were gathered and evaluated. Conclusion: The aim of this study was to thoroughly present an updated review of the TNBS-induced colitis protocols that are implemented by researchers. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.

引用

页码：9 / 15

页数：7

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