HLA-DR ANTIGEN-POSITIVE AND S-100 PROTEIN-POSITIVE DENDRITIC CELLS IN ESOPHAGEAL SQUAMOUS-CELL CARCINOMA - THEIR DISTRIBUTION IN RELATION TO PROGNOSIS

被引:63
|
作者
FURIHATA, M
OHTSUKI, Y
IDO, E
IWATA, J
SONOBE, H
ARAKI, K
OGOSHI, S
OHMORI, K
机构
[1] KOCHI MED SCH, DEPT SURG 1, NANKOKU, KOCHI 78151, JAPAN
[2] KOCHI MED SCH, DEPT SURG 2, NANKOKU, KOCHI 78151, JAPAN
[3] MATSUYAMA SHIMIN HOSP, DIV SURG, MATSVYAMA, JAPAN
关键词
HLA-DR; S-100; PROTEIN; DENDRITIC CELL; ESOPHAGEAL CARCINOMA; IMMUNOHISTOCHEMISTRY;
D O I
10.1007/BF02890444
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The distribution of immunohistochemically labeled HLA-DR antigen- and S-100 protein-positive dendritic cell (DR + DC and S100 + DC) was investigated in 59 human esophageal squamous cell carcinomas (SCCs). A dense infiltration of both DR + DC and S100 + DC was detected in 11, only DR + DC in two, and only S100 + DC in one. In the remaining 45 tumors infiltrating DC were sparse. By means of double immunostaining or the mirror section method, three different types of DC, namely S-100-negative and HLA-DR-positive DC(S100-DR + DC), S-100-positive and HLA-DR-negative DC(S100 + DR-DC) and double-positive DC(S100 + DR + DC) were clearly identified. With regard to postoperative survival, these patients with tumors in which there was a dense infiltration of DR + DCs and/or S100 + DCs showed a significantly better survival rate than those in which DC were sparse (DR + DCs - P < 0.001; S100 + DCs - P < 0.01). These results indicate that DC infiltration may be a prognostic factor in esophageal SCCs.
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页码:409 / 414
页数:6
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