AN ATP-INDEPENDENT CATENATING ENZYME FROM THE KINETOPLAST HEMOFLAGELLATE LEISHMANIA-DONOVANI

被引：26

作者：

CHAKRABORTY, AK ^{[1
]}

MAJUMDER, HK ^{[1
]}

机构：

[1] INDIAN INST CHEM BIOL, MOLEC PARASITOL LAB, LEISHMANIA GRP, 4 RAJA SC MULLICK RD, Kolkata 700032, W BENGAL, INDIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 180卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)81289-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An enzyme from Leishmania donovani that catenates monomeric pBR322 into huge catenanes has been isolated and characterized. The enzyme also decatenates kinetoplast DNA networks into covalently closed monomeric circles and relaxes supercoiled pBR322. The catenation, decatenation and relaxation reactions do not require ATP. The formation of topological isomers of unique linking numbers suggest that the enzyme is a type II DNA topoisomerase. © 1991 Academic Press, Inc.

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页码：279 / 285

页数：7

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