INFLUENCE OF DNA-REPAIR DEFICIENCIES ON THE UV SENSITIVITY OF YEAST-CELLS IN DIFFERENT CELL-CYCLE STAGES

被引：23

作者：

SIEDE, W ^{[1
]}

FRIEDBERG, EC ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT PATHOL,STANFORD,CA 94305

来源：

MUTATION RESEARCH | 1990年 / 245卷 / 04期

关键词：

Cell cycle; DNA-repair deficiencies; Excision repair; Rad genes; UV sensitivity; Yeast;

D O I：

10.1016/0165-7992(90)90158-G

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Synchronously dividing haploid yeast cells were UV-irradiated in various stages of the cell cycle after release from α-factor arrest. In confirmation of earlier results (Chanet et al., 1973), in wild-type strains G1/S phase cells were found to be the most sensitive and late S/G2 cells the most resistant. Stationary-phase (G0) cells were significantly more UV resistant than G1 cells. Strains defective in nucleotide excision repair lost enhanced resistance in the G2 phase and were most UV-sensitive in the Go state. Reduced G2 resistance was also observed in rad6 mutants but not in rad9 mutants. After UV-irradiation in G1 phase rad9 mutant cells showed a reduced G1/S phase arrest. © 1990.

引用

页码：287 / 292

页数：6

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