MAPPING THE TRANSITION-STATE AND PATHWAY OF PROTEIN FOLDING BY PROTEIN ENGINEERING

被引：655

作者：

MATOUSCHEK, A ^{[1
]}

KELLIS, JT ^{[1
]}

SERRANO, L ^{[1
]}

FERSHT, AR ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT CHEM,MRC,PROT FUNCT & DESIGN UNIT,LENSFIELD RD,CAMBRIDGE CB2 1EW,ENGLAND

来源：

NATURE | 1989年 / 340卷 / 6229期

关键词：

D O I：

10.1038/340122a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：122 / 126

页数：5

共 21 条

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[6] STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS - ANALYSIS OF USE OF BINDING-ENERGY BY LINEAR FREE-ENERGY RELATIONSHIPS [J].

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[8] EFFECTS OF MULTIPLE REPLACEMENTS AT A SINGLE POSITION ON THE FOLDING AND STABILITY OF DIHYDROFOLATE-REDUCTASE FROM ESCHERICHIA-COLI [J].

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[9] MUTATIONAL ANALYSIS OF A PROTEIN-FOLDING PATHWAY [J].

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[10] CONTRIBUTION OF HYDROPHOBIC INTERACTIONS TO PROTEIN STABILITY [J].

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