ANTENATAL DIAGNOSIS OF HEMOGLOBINOPATHIES BY BIOREX CHROMATOGRAPHY OF HEMOGLOBIN

被引：13
|
作者：
BLOUQUIT, Y
BEUZARD, Y
VARNAVIDES, L
CHABRET, C
DUMEZ, Y
JOHN, PN
RODECK, C
WHITE, JM
机构：
[1] HOP HENRI MONDOR, INSERM, U91, UNITE RECH ANEMIES, F-94010 CRETEIL, FRANCE
[2] HOP HENRI MONDOR, BIOCHIM LAB, F-94010 CRETEIL, FRANCE
[3] MATERN PORT ROYAL, F-75014 PARIS, FRANCE
[4] UNIV LONDON KINGS COLL HOSP, SCH MED, DEPT OBSTET & GYNAECOL, LONDON SE5 8RX, ENGLAND
[5] UNIV LONDON KINGS COLL HOSP, SCH MED, DEPT HAEMATOL, LONDON SE5 8RX, ENGLAND
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1982年 / 50卷 / 01期
关键词：
D O I：
10.1111/j.1365-2141.1982.tb01885.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Biorex chromatography of Hb was compared to the standard chromatographic separation of radioactive globin chains in 60 [human] fetal blood samples obtained for the antenatal diagnosis of hemoglobinopathies. Biorex chromatography of Hb permitted 2 measurements, the optical density at 418 nm and the radioactivity incorporated into fetal and adult Hb. The 2 measurements were highly correlated (r2 = 0.96) and enabled a distinction between homozygous from heterozygous states of the diseases to be made, particularly in .beta. thalassemia. A single column was used for 50 analyses. This fast and very sensitive method is proposed for the antenatal diagnosis of hemoglobinopathies using fetal blood.
引用
收藏
页码：7 / 15
页数：9
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