STUDY OF INFLUENCE OF BODY ADIPOSITY ON INSULIN RESISTANCE IN PCOS

被引:0
作者
Prathiba, S. [1 ]
Girijasivam, S. P. [1 ]
Shankar, Ravi N. [1 ]
机构
[1] Chengalpattu Med Coll, Dept Physiol, Chengalpattu, Tamil Nadu, India
来源
JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS | 2016年 / 5卷 / 94期
关键词
PCOS; Obesity; Insulin Resistance; HOMA-IR;
D O I
10.14260/jemds/2016/1563
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND PCOS is a most common metabolic endocrine disorder affecting women of reproductive age group. Prevalence of obesity and overweight is observed more in patients with PCOS. The exact cause of PCOS remains unknown till now. Insulin resistance is considered to be a prime factor in the pathogenesis of PCOS. Insulin resistance may present in PCOS independent of obesity. Our study is aimed to investigate the role of adiposity with insulin resistance in patients with PCOS by evaluating the insulin resistance index in obese and non-obese PCOS patients. MATERIALS AND METHODS 100 women with PCOS diagnosed as per Rotterdam's criteria of age 20-30 years were selected as study subjects for this crosssectional study. They were divided into 2 groups as obese and non-obese PCOS based on BMI. Fasting insulin, fasting glucose and fasting total cholesterol were measured. HOMA-IR was calculated with these values. Statistical analysis was done using student 't' test SPSS version 17. RESULTS Fasting blood sugar differed significantly and highly significant difference was obtained in fasting insulin and HOMA-IR values among the study groups. CONCLUSION Although, high HOMA-IR values (> 2.5) were observed in both obese and non-obese PCOS groups, significantly higher values were obtained in obese PCOS group. Body adiposity aggravates insulin resistance in PCOS patients.
引用
收藏
页码:6906 / 6908
页数:3
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