NMR-STUDIES OF DRUGS - CHIRAL SOLVATING AGENTS FOR DIRECT DETERMINATION OF ENANTIOMERIC EXCESS OF THE CARDIAC ANTIARRHYTHMIC, MEXILETINE

被引：4

作者：

ABOULENEIN, HY

ROTHCHILD, R

SINNEMA, A

机构：

[1] CUNY JOHN JAY COLL CRIMINAL JUSTICE,DEPT SCI,TOXICOL RES & TRAINING CTR,NEW YORK,NY 10019

[2] DELFT UNIV TECHNOL,FAC CHEM TECHNOL & MAT SCI,ORGAN CHEM & CATALYSIS LAB,2628 BL DELFT,NETHERLANDS

来源：

SPECTROSCOPY LETTERS | 1992年 / 25卷 / 08期

关键词：

OPTICAL PURITY; ENANTIOMER; ANALYSIS; 1-(2,6-DIMETHYLPHENOXY)-2-PROPANAMINE; ANTIARRHYTHMIC; CYCLODEXTRIN; ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL) PHENYLACETIC ACID; MTPA; 2,2,2-TRIFLUORO-1-(9-ANTHRYL)ETHANOL; TFAE;

D O I：

10.1080/00387019208017870

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The 400 MHz H-1 NMR spectra of the cardiac antiarrhythmic, mexiletine, 1, have been studied with different chiral solvating agents (CSA) to obtain a very promising method for direct determination of enantiomeric excess (e.e.) with limited amounts of 1. The methods included the use of beta-cyclodextrin (beta-CD), gamma-cyclodextrin (gamma-CD), alpha-methoxy-alpha-(trifluoromethyl)phenylacetic acid (MTPA), and 2,2,2-trifluoro-1-(9-anthryl)ethanol (TFAE) . Use of TFAE in CDCl3 with the free base of 1 appeared to give the best results, with enantiomeric shift differences observed for the signals of the sidechain methyl, CH3CH, and the aryl methyls.

引用

页码：1367 / 1385

页数：19

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