SYNTHESIS AND NMR-STUDIES OF SOME STEROIDAL ISOXAZOLES

被引：0
|
作者：
GIACOPELLO, S [1 ]
DELUCA, ME [1 ]
SELDES, AM [1 ]
机构：
[1] UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT,DEPT QUIM ORGAN,PABELLON 2,RA-1428 BUENOS AIRES,ARGENTINA
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 1992年 / 47卷 / 06期
关键词：
ANABOLIC AGENTS; ISOXAZOLINIC STEROIDS; 17-ALPHA-PREGNA-2,4-DIEN-[2,3-D]ISOXAZOL-17-BETA-OL; SYNTHESIS; NMR SPECTRA;
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A short synthesis of 17-alpha-pregna-2,4-dien-[2,3-d]isoxazol-17-beta-ol (1) is described using mild reaction conditions and with a high overall yield. The equilibrium between keto-enolic forms has been studied by H-1 NMR methods. Complete assignments of all the resonances in the H-1 and C-13 NMR spectra of Danazol have been made using a variety of one and two-dimensional correlation methods. C-13 NMR spectra of all the intermediate and related model compounds were also assigned.
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页码：891 / 897
页数：7
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