POLYAMINE AND IFENPRODIL INTERACTIONS WITH THE NMDA RECEPTORS GLYCINE SITE

被引：29

作者：

RANSOM, RW

机构：

[1] Merck Sharp and Dohme Research Laboratories, Department of New Lead Pharmacology, West Point

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1991年 / 208卷 / 01期

关键词：

N-METHYL-D-ASPARTATE (NMDA); IFENPRODIL; POLYAMINES; GLYCINE;

D O I：

10.1016/0922-4106(91)90052-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ifenprodil partially inhibited [H-3]glycine binding to the N-methyl-D-aspartate (NMDA) receptor in rat telencephalic membranes. The polyamine spermine significantly enhanced [H-3]glycine binding and decreased ifenprodils inhibitory potency. However, ifenprodil was unable to completely reverse the stimulation of binding produced by spermine. Also, ifenprodil was found to reduce the maximum degree to which spermine enhanced binding but had no effect on the polyamine's potency. These results show that ifenprodil and spermine do not competitively interact with respect to their abilities to modify [H-3]glycine binding to the NMDA receptor complex.

引用

页码：67 / 71

页数：5

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